Article

Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

2022-09-04

Abstract excerpt

Somatic activating mutations of PIK3CA are associated with the development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA -driven VMs consisting of human umbilical vein endothelial cells (HUVECs) expressing PIK3CA activating mutations embedded in 3D hydrogels. We observed enlarged and irregular vessel phenotypes, consistent with clinical signatures and concomitant with PI3K-dr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd878336-4e14-5a21-a872-adda84c9ac26
DOI: 10.1101/2022.09.03.506415

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationDOI 10.1101/2022.09.03.506415Read

PI3K/AKT/mTOR axis in vascular malformations: from molecular insights to targeted clinical trials.Semantic proximity Read

Vascular malformations: An overview of their molecular pathways, detection of mutational profiles and subsequent targets for drug therapySemantic proximity Read

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformationsSemantic proximity Read

New and Emerging Targeted Therapies for Vascular Malformations.Semantic proximity Read

PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.Semantic proximity Read

Genetic Causes of Vascular Malformations and Common Signaling Pathways Involved in Their Formation.Semantic proximity Read

Molecular landscape and classification of vascular anomalies.Semantic proximity Read

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human diseaseSemantic proximity Read

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Semantic proximity Read

Syndromic vascular malformations related to the PIK3CA and RAS pathways: A clinical and imaging review.Semantic proximity Read

AKT-mTOR/P53 PathwayDriven RapamycinAlpelisib Efficacy in Animal Models of TIE2Mutant Venous Malformations.Semantic proximity Read

Comprehensive phenotypic and genomic characterization of venous malformations.Semantic proximity Read