Article

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

2021-02-08

Abstract excerpt

<h4>Summary</h4> By mirroring their function as tissue repair organizers in normal tissues, immune cells regulate tumor growth. To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, we generated a penetrant double oncogene-driven autochthonous model of neuroblastoma. Using spatial transcri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5500171-607f-5c7f-960e-8149f54dbd98
DOI: 10.1101/2021.02.08.430292

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolismDOI 10.1101/2021.02.08.430292Read

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid CellsSemantic proximity Read

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneitySemantic proximity Read

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in NeuroblastomaSemantic proximity Read

Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiringSemantic proximity Read

The neuroblastoma tumor microenvironment: From an in-depth characterization towards novel therapiesSemantic proximity Read

Tumor Microenvironment in Neuroblastoma and Immunotherapeutic Approaches: Towards More Effective TreatmentSemantic proximity Read

The immune cell atlas of human neuroblastomaSemantic proximity Read

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticitySemantic proximity Read

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactionsSemantic proximity Read

Single cell view of tumor microenvironment gradients in pleural mesotheliomaSemantic proximity Read

Lineage and Spatial Mapping of Glioblastoma-associated ImmunitySemantic proximity Read

Spatially resolved T cell receptor tracking reveals γδT cell localization to tumor-rich regions in high-risk neuroblastoma: A Report from the Children’s Oncology GroupSemantic proximity Read