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Article

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma

18 Jul 2017

Abstract excerpt

Abstract Ewing sarcoma is a bone malignancy driven by a translocation event resulting in the fusion protein EWS/FLI1 (EF). EF functions as an aberrant and oncogenic transcription factor that misregulates the expression of thousands of genes. Previous work has focused principally on determining important transcriptional targets of EF, as well as characterizing important regulatory partnerships in EF-dependent...

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PMID: 28720588
DOI: 10.1158/1541-7786.mcr-17-0182

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