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Article

Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.

Biochemical and biophysical research communications - 29 Mar 2013

Cheng Zhang, Tsuda Manabu, Kishita Yoshihito, Sato Yukiko, Aigaki Toshiro

Abstract excerpt

Aconitase catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid (TCA) cycle, and its deficiency in humans is associated with an infantile neurodegenerative disorder affecting mainly the cerebellum and retina. Here we investigated the effect of gene knockout and knockdown of the mitochondrial aconitase Acon in Drosophila. Acon-knockout flies were homozygous lethal, indicating that Acon is...

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Identifiers

PMID: 23438437
DOI: 10.1016/j.bbrc.2013.02.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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