Article

G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer.

2023-05-23

Abstract excerpt

<title>Abstract</title> <p>p38γ (MAPK12) is predominantly expressed in triple negative breast cancer cells (TNBC) and induces stem cell (CSC) expansion resulting in decreased survival of the patients due to metastasis. Abundance of G-rich sequences at MAPK12 promoter implied the functional probability to reverse tumorigenesis, though the formation of G4 structures at MAPK12 promoter is elusive. Here, we identifie...

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Literature Corpus work: 57e41e78-7d47-5eb8-a1df-fd0b7ff98369
DOI: 10.21203/rs.3.rs-2919879/v1

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G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer.DOI 10.21203/rs.3.rs-2919879/v1Read

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