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Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes<i>ATP8B4, FCGR1A</i>, and<i>LILRB1</i>that associate with Alzheimer’s disease

2022-07-13

Abstract excerpt

<h4>Background</h4> Alterations in innate immunity are pathologically associated with and genetically implicated in Alzheimer’s disease (AD). In the whole exome sequence (WES) dataset generated by the Alzheimer’s Disease Sequencing Project (ADSP), only the previously identified p.R47H variant in the innate immunity gene, TREM2 , shows study-wide association with risk of AD. Using a novel approach, we searched the...

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Literature Corpus work
57e0c663-ab87-5707-a028-de2d446d39e4
DOI
10.1101/2022.07.12.22277557
Open publication

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Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes<i>ATP8B4, FCGR1A</i>, and<i>LILRB1</i>that associate with Alzheimer’s diseaseDOI 10.1101/2022.07.12.22277557
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