Article

Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer’s disease.

2022-08-03

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Alterations in innate immunity are pathologically associated with and genetically implicated in Alzheimer’s disease (AD). In the whole exome sequence (WES) dataset generated by the Alzheimer’s Disease Sequencing Project (ADSP), only the previously identified p.R47H variant in the innate immunity gene, <italic>TREM2</italic>, shows study-wide association with ris...

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Literature Corpus work: 66fe7c5d-10df-5f6d-9a37-9973786e4109
DOI: 10.21203/rs.3.rs-1885551/v1

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