Article

Thermodynamic coupling between folding correctors and the first of dimerized nucleotide binding domains in CFTR

2025-06-17

Abstract excerpt

<title>Abstract</title> <p>The most common cystic fibrosis mutation is the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (hCFTR), which causes misfolding of the first of two nucleotide binding domains (NBD1/2), preventing Mg/ATP-dependent NBD dimerization for normal function. Although folding correctors elexacaftor/VX-445 and lumacaftor/VX-809 have been combined to correct the...

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Literature Corpus work: 0fe760a0-c29b-554e-8242-91944865b8b0
DOI: 10.21203/rs.3.rs-6890276/v1

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