Article

ATP-dependent thermoring basis for the heat unfolding of the first nucleotide-binding domain isolated from human CFTR

2024-11-21

Abstract excerpt

<title>Abstract</title> <p>Traditionally, the thermostability of a protein is defined by a melting temperature, at which half of the protein is unfolded. However, this definition cannot indicate the structural origin of a heat-induced unfolding pathway. Here, the thermoring structures were studied on the ATP-dependent heat-induced unfolding of the first nucleotide-binding domain from the human cystic fibrosis tra...

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Literature Corpus work: 3a36db17-1e9a-56f4-a063-eff0320e7412
DOI: 10.21203/rs.3.rs-5479740/v1

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