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Article

Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations.

Cellular and molecular life sciences : CMLS - 1 Sept 2005

Eudes R, Lehn P, Férec C, Mornon J-P, Callebaut I

Abstract excerpt

Defective function of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) causes CF, the most frequent lethal inherited disease among the Caucasian population. The structure of this chloride ion channel includes two nucleotide-binding domains (NBDs), whose ATPase activity controls channel gating. Recently, the experimental structures of mouse and human CFTR NBD1 and our model of the human CFTR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16132229
DOI: 10.1007/s00018-005-5224-y
PMCID: PMC11139114

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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