Article

A Topological Switch in the Cystic Fibrosis Transmembrane Conductance Regulator Modulates Channel Activity and Sensitivity to Disease-Causing Mutation

2020-12-08

Abstract excerpt

<title>Abstract</title> <p>The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is essential to maintain fluid homeostasis in key organs such as the lungs or the digestive systems. Functional impairment of CFTR due to mutation in the cftr gene lead to Cystic Fibrosis (CF) the most common lethal genetic disorder. Here we observe that the first nucleotide-binding domain (NBD1) of CFTR can sp...

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Literature Corpus work: 254cb43d-12d0-5382-a33a-06af7411deb6
DOI: 10.21203/rs.3.rs-110567/v1

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