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Article

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Nature communications - 27 Oct 2023

Soya Naoto, Xu Haijin, Roldan Ariel, Yang Zhengrong, Ye Haoxin, Jiang Fan, Premchandar Aiswarya, Veit Guido, Cole Susan P C, Kappes John, Hegedüs Tamás, Lukacs Gergely L

Abstract excerpt

The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2) and transmembrane domains (TMD1,2). Using molecular dynamic simulations, biochemical and hydrogen deuterium exchange approaches, we show that the...

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Identifiers

PMID: 37891162
DOI: 10.1038/s41467-023-42586-8
PMCID: PMC10611759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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