Article

Novel Approach for Obtaining VNAR with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)

2023-10-03

Abstract excerpt

Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties. The phage display method used to screen for optimal VNARs loses sequence diversity because of the bias caused by the differential ease of protein expression in Escheri...

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Literature Corpus work: 579d687d-c6df-5a8d-9401-05166c1c1e17
DOI: 10.20944/preprints202310.0150.v1

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