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VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)

12 Sept 2023

Abstract excerpt

The VNAR (Variable New Antigen Receptor) is the smallest single-domain antibody derived from the variable domain of IgNAR of cartilaginous fishes. Despite its biomedical and diagnostic potential, research on VNAR has been limited due to the difficulties in obtaining and maintaining immune animals and the lack of research tools. In this study, we investigated the Japanese topeshark as a promising immune animal for...

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PMID: 37771574
DOI: 10.3389/fbioe.2023.1265582

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