Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview

Abstract excerpt

Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements as they combine the advantages of the specificity and affinity found in conventional antibodies with high stability and solubility. Melting temperatures (Tms) of sdAbs cover a wide range from below 50 to over 80 °C. Many sdAbs have been engineered to increase their Tm, making them stable until exposed to extreme...

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