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Bamboo Shark as a Small Animal Model for Single Domain Antibody Production

8 Dec 2021

Abstract excerpt

) being cultivated commercially as a promising small animal model to produce sdAbs. We found that immunoglobulin new antigen receptor (IgNAR) presented in bamboo shark genome, transcriptome, and plasma. Four complete IgNAR clusters including variable domains (vNARs) were discovered in the germline, and the Variable-Joining pair from IgNAR1 cluster was dominant from immune repertoires in blood. Bamboo sharks...

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PMID: 34957081
DOI: 10.3389/fbioe.2021.792111

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