Article

Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation

2025-01-01

Abstract excerpt

HTT1a was identified in human and mouse Huntington’s disease brain as the pathogenic exon 1 mRNA generated from aberrant splicing between exon 1 and 2 of HTT that contributes to aggregate formation and neuronal dysfunction. 1 Detection of the huntingtin exon 1 protein (HTT1a) has been accomplished with fluorescence-based reporter assays (Meso Scale Discovery, Homogeneous Time Resolved Fluorescence) and immunopre...

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Literature Corpus work: 76e15da4-00a5-5b68-bd6f-53c6c0f31588
DOI: 10.1101/2024.12.31.630891

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