Article

Effects of Pathological Mutations on the Prion-Like Polymerisation of MyD88

2018-06-20

Abstract excerpt

A novel concept has emerged whereby the higher-order self-assembly of proteins provides a simple and robust mechanism for signal amplification. This appears to be a universal signalling mechanism within the innate immune system, where the recognition of pathogens or danger-associated molecular patterns need to trigger a strong, binary response within cells. Previously, multiple structural studies have been limited...

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Literature Corpus work: 57862312-8630-55cb-ab15-aad8bc2cf37f
DOI: 10.1101/351726

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