MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.

doi:10.1038/s41467-021-22590-6

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Article

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.

Nature communications - 10 May 2021

Clabbers Max T B, Holmes Susannah, Muusse Timothy W, Vajjhala Parimala R, Thygesen Sara J, Malde Alpeshkumar K, Hunter Dominic J B, Croll Tristan I, Flueckiger Leonie, Nanson Jeffrey D, Rahaman Md Habibur, Aquila Andrew, Hunter Mark S, Liang Mengning, Yoon Chun Hong, Zhao Jingjing, Zatsepin Nadia A, Abbey Brian, Sierecki Emma, Gambin Yann, Stacey Katryn J, Darmanin Connie, Kobe Bostjan, Xu Hongyi, Ve Thomas

Abstract excerpt

MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order assemblies of the MyD88 TIR domain (MyD88TIR). These crystals are too small for conventional X-ray crystallography, but are ideally suited to structure determination by...

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PMID: 33972532
DOI: 10.1038/s41467-021-22590-6
PMCID: PMC8110528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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