Structural insights into the role of deleterious mutations at the dimeric interface of TRAM protein

Abstract excerpt

Toll-like receptors (TLRs) are major players of the innate immune system – recognizing pathogens and differentiating self/non-self components of immunity. These proteins are present either on the plasma membrane or endosome and recognise pathogens at their extracellular domains. They are also characterised by a single transmembrane helix and an intracellular TIR domain. Few TIRs directly invoke downstream signalli...

Topics

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• Adaptor Proteins, Signal Transducing
• Adaptor Proteins, Vesicular Transport
• Binding Sites
• Molecular Dynamics Simulation
• Protein Conformation, alpha-Helical
• Protein Interaction Domains and Motifs
• Protein Multimerization
• Toll-Like Receptor 4

Identifiers and source

Literature Corpus work

53da27ed-7c21-5d04-85ec-0e0d139db4ad

DOI

10.22541/au.168534396.69412137/v1