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Article

Structural insights into the role of deleterious mutations at the dimeric interface of Toll-like receptor interferon-β related adaptor protein.

Proteins - 1 Oct 2024

Verma Shailya, Menon Revathy, Sowdhamini Ramanathan

Abstract excerpt

Toll-like receptors (TLRs) are major players in the innate immune system-recognizing pathogens and differentiating self/non-self components of immunity. These proteins are present either on the plasma membrane or endosome and recognize pathogens at their extracellular domains. They are characterized by a single transmembrane helix and an intracellular toll-interleukin-1 receptor (TIR) domain. Few TIRs directly...

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Share to Adaptor Proteins, Signal Transducing
Share to Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Dynamics Simulation

Share to Protein Conformation, alpha-Helical

Share to Protein Interaction Domains and Motifs

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Source

Identifiers

PMID: 38814166
DOI: 10.1002/prot.26707

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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