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Article

Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.

Protein engineering, design & selection : PEDS - 1 Sept 2016

Zhan Chendi, Qi Ruxi, Wei Guanghong, Guven-Maiorov Emine, Nussinov Ruth, Ma Buyong

Abstract excerpt

MyD88 is an essential adaptor protein, which mediates the signaling of the toll-like and interleukin-1 receptors' superfamily. The MyD88 L252P (L265P) mutation has been identified in diffuse large B-cell lymphoma. The identification of this mutation has been a major advance in the diagnosis of patients with aldenstrom macroglobulinemia and related lymphoid neoplasms. Here we used computational methods to...

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Identifiers

PMID: 27503954
DOI: 10.1093/protein/gzw033
PMCID: PMC5001137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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