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Article

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site.

Journal of cell science - 15 Jan 2010

Ulrichts Peter, Bovijn Celia, Lievens Sam, Beyaert Rudi, Tavernier Jan, Peelman Frank

Abstract excerpt

Toll-like receptors (TLRs) are crucial components of innate immunity, ensuring efficient responses against invading pathogens. After ligand binding, TLR signaling is initiated by recruitment of adaptor molecules, a step mediated by homotypic Toll-IL-1 receptor (TIR) domain interactions. Four TIR-...

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Share to Caspase 1
Share to Mutant Proteins
Share to Myeloid Differentiation Factor 88

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-kappa B

Share to Receptors, Interleukin-1

Share to Toll-Like Receptor 4

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Source

Identifiers

PMID: 20048342
DOI: 10.1242/jcs.056002

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20048342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site.PMID 20048342Read ↗

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