Article

Enhancer Promoter Interactome and Mendelian Randomization Identify Network of Druggable Vascular Genes in Coronary Artery Disease

2021-11-01

Abstract excerpt

<title>Abstract</title> Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anchor loops from human coronary artery smooth muscle cells (HCASMC) explained 22% of the heritabilit...

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Literature Corpus work: 5773e22b-b9fa-56da-9518-973bcc7089f8
DOI: 10.21203/rs.3.rs-978033/v1

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