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Article

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease.

Human genomics - 4 Mar 2022

Chignon Arnaud, Mathieu Samuel, Rufiange Anne, Argaud Déborah, Voisine Pierre, Bossé Yohan, Arsenault Benoit J, Thériault Sébastien, Mathieu Patrick

Abstract excerpt

Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anchor loops from human coronary artery smooth muscle cells (HCASMC) explained 22% of the heritability for CAD. 3D...

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35246263
DOI: 10.1186/s40246-022-00381-4
PMCID: PMC8895522

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