Article

Stromal Gasdermin D-mediated Pyroptosis Drives Maladaptive CD4⁺ T-cell Remodeling in Tet2-Deficient Hematopoiesis

2026-05-05

Abstract excerpt

An inflammatory bone marrow microenvironment is increasingly recognized as critical in myeloid disease evolution, yet how stromal inflammation interfaces with adaptive immunity remains poorly defined. Here, we show that stromal pyroptosis drives mutation-specific myeloid expansion by coordinating monocytic remodeling and CD4⁺ T-cell activation. Genetic ablation of gasdermin D in the bone marrow stroma suppressed s...

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Literature Corpus work: 40592191-e661-5e2c-8e87-6bf3d3e7055f
DOI: 10.64898/2026.05.01.722102

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