Article

Metabolic engineering of <i>Escherichia coli</i> to modulate hydrogen sulfide levels in the mammalian gut

2026-07-24

Abstract excerpt

Hydrogen sulfide (H 2 S) is a microbiota-derived metabolite in the gastrointestinal tract implicated in a number of diseases. Its volatility and reactivity make experimentally controlling H 2 S concentration in vivo difficult, limiting our ability to interrogate its dose-dependent effects on host physiology. Engineered bacteria present a compelling solution, yet most probiotic metabolic engineering approaches h...

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Literature Corpus work: bcb5b7ab-7967-5aa6-a8ae-2b68cf411e54
DOI: 10.64898/2026.07.23.738723

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