Article

An in vivo genome-wide CRISPR-Cas9 screen identifies FER as a tumor suppressor inhibiting the oncogenic transformation

2023-06-28

Abstract excerpt

<title>Abstract</title> <p>Background Tumorigenesis is a complex and multistep process characterized by the progressive acquisition of various hallmarks, including unlimited proliferation, resistance to apoptosis, and increased invasiveness and metastasis. However, the molecular mechanisms underlying tumorigenesis remain poorly understood. Methods An in vivo genome-wide CRISPR–Cas9 screen was employed to identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 574142b2-b218-5d35-a276-658cefba127a
DOI: 10.21203/rs.3.rs-3036525/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An in vivo genome-wide CRISPR-Cas9 screen identifies FER as a tumor suppressor inhibiting the oncogenic transformationDOI 10.21203/rs.3.rs-3036525/v1Read

Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction.Semantic proximity Read

Characterizing genes associated with cancer using the CRISPR/Cas9 system: A systematic review of genes and methodological approaches.Semantic proximity Read

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter systemSemantic proximity Read

Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancerSemantic proximity Read

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.Semantic proximity Read

CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future ResearchSemantic proximity Read

Unveiling the Mechanisms to Bypass KRAS Inhibition: <i>In Vitro</i> Insights into the Influence of Fibroblast-SecretomeSemantic proximity Read

CRISPR/Cas9 editing of the genome for cancer modeling.Semantic proximity Read

Genome-scale CRISPR-Cas9 screen identifies PAICS as a therapeutic target for EGFR wild-type NSCLCSemantic proximity Read

CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genesSemantic proximity Read

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.Semantic proximity Read

Application of CRISPR/Cas9 screening to study cancer drivers and to identify novel cancer vulnerabilitiesSemantic proximity Read