Article
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
Scientific reports - 20 Nov 2019
Huang Jianguo, Chen Mark, Xu Eric S, Luo Lixia, Ma Yan, Huang Wesley, Floyd Warren, Klann Tyler S, Kim So Young, Gersbach Charles A, Cardona Diana M, Kirsch David G
Abstract excerpt
Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mesenchymal and epithelial cells in vitro and in vivo. Identifying other genes that can cooperate with oncogenic Kras and substitute for Trp53 mutation has the potential...
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