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Unveiling the Mechanisms to Bypass KRAS Inhibition: <i>In Vitro</i> Insights into the Influence of Fibroblast-Secretome

2024-04-23

Abstract excerpt

Novel KRAS-targeted therapies unlocked new treatment options for previously untreatable patients. However, in colorectal cancer (CRC), resistance to KRAS-targeted therapy develops rapidly, making it imperative to understand its underlying mechanisms. Cancer-associated fibroblasts (CAFs) induce therapy resistance by generating and maintaining cancer stem cells (CSCs). Additionally, CAFs secretome can modulate KRAS...

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Literature Corpus work
a3d96a5e-cc4f-51b0-b978-6a119d718c00
DOI
10.1101/2024.04.19.590324
Open publication

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