Article

Genome-scale CRISPR-Cas9 screen identifies PAICS as a therapeutic target for EGFR wild-type NSCLC

2023-03-14

Abstract excerpt

<title>Abstract</title> <p>EGFR-targeted therapies for NSCLC have made promising progress, whereas one-third of NSCLC patients do not benefit from them due to lack of EGFR mutations. Therefore, personalized molecular-targeted therapies are urgently needed for EGFR wild-type NSCLC patients. Genome-wide CRISPR/Cas9 screen was performed in EGFR wild-type NSCLC cell lines to identify NSCLC-specific essential genes as...

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Literature Corpus work: b011e267-c246-5bdc-ba7b-2355099e9e5e
DOI: 10.21203/rs.3.rs-2608044/v1

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