Article

Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers

2021-08-11

Abstract excerpt

<h4>ABSTRACT</h4> One of the least understood aspects of prion diseases is the structure of infectious prion protein aggregates. Here we report a high-resolution cryo-EM structure of amyloid fibrils formed by human prion protein with Y145Stop mutation that is associated with a familial prion disease. This structural insight allows us not only to explain previous biochemical findings, but also provides direct supp...

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Literature Corpus work: 572faf0f-ea19-5acd-8ba9-7234400f9d9b
DOI: 10.1101/2021.08.10.455830

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