Article

Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

2020-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis and several other neurodegenerative diseases are associated with brain deposits of TDP-43 aggregates. Cryo-EM structure of amyloid formed from the entire TDP-43 low complexity domain reveals single protofilament fibrils containing a large (138-residue), tightly packed core with structural features that differ from those previously found for fibrils formed from short...

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Literature Corpus work: 184c3121-e4b2-58df-9584-83add7f0bde2
DOI: 10.1101/2020.12.14.422689

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