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Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

2021-07-09

Abstract excerpt

Synucleinopathies are neurodegenerative diseases related to the aggregation of the protein alpha-synuclein (aSyn). Among these diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA) are most prevalent. aSyn can readily form different fibrillar polymorphs, if exposed to an air-water interface or by templating with pre-existing fibrils. We here report the structures of three fibrillar polymorphs that w...

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Identifiers and source

Literature Corpus work
1c3533c4-e41f-5f6a-90d9-38daeeecc12e
DOI
10.1101/2021.07.08.451588
Open publication

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Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brainsDOI 10.1101/2021.07.08.451588
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