Article

Understanding the heterogeneity of alloreactive natural killer cell function in kidney transplantation

2023-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Human Natural Killer (NK) cells are heterogeneous lymphocytes regulated by variegated arrays of germline-encoded activating and inhibitory receptors. They acquire the ability to detect polymorphic self-antigen via NKG2A/HLA-E or KIR/HLA-I ligand interactions through an education process. Correlations among HLA/KIR genes, kidney transplantation pathology and outcomes suggest that NK cells partici...

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Literature Corpus work: 571f206e-5a2b-53ff-82a5-2114cf5ca19f
DOI: 10.1101/2023.09.01.555962

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