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Donor and host coexpressing KIR ligands promote NK education after allogeneic hematopoietic stem cell transplantation

23 Dec 2019

Abstract excerpt

The rate and extent of natural killer (NK)-cell education after hematopoietic cell transplantation correlates with leukemia control. To study the effect of donor and host HLA on NK-cell reconstitution, single killer-cell immunoglobulin-like receptor (KIR)+ NK cells (exhibiting KIR2DL1, KIR2DL2/KIR2DL3, or KIR3DL1 as their sole receptor) were grouped into 4 groups based on the interaction between donor/host HLA...

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PMID: 31869417
DOI: 10.1182/bloodadvances.2019000242

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