Article

<i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study

2025-05-11

Abstract excerpt

<h4>Background</h4> Evidence for involvement of NK cells and monocytes as prime agents in the process of human kidney transplant rejection is expanding quickly. These cells express FCGR3A, used for antibody-dependent cellular cytotoxicity (ADCC) after engagement with donor-specific antibodies on graft cells. A functional genetic polymorphism in the Fc fragment of IgG IIIa receptor (CD16a) gene ( FCGR3A ) results i...

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Literature Corpus work: 342d19dd-bd24-5ce4-ba05-67db57b2fce4
DOI: 10.1101/2025.05.09.25327308

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