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Article

<i>Dcaf17</i> knockdown integrates mitochondrial-lysosomal dysfunction with ferroptosis, NLRP3 inflammasome signaling and necroptosis

2025-06-05

Abstract excerpt

DCAF17 (DDB1-and CUL4-associated factor 17) plays a vital role in spermatogenesis, influencing post-meiotic sperm development. Its dysfunction leads to male infertility, as demonstrated in our previous study on Dcaf17 knockout mice, which revealed impaired sperm morphogenesis, increased numbers of dysmorphic and immotile sperm, and complete male infertility. Mutations in the human Dcaf17 gene have been implicate...

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Literature Corpus work
571a9204-c5f1-5fd9-8023-647d329b6881
DOI
10.1101/2025.06.04.657829
Open publication

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