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Article

PDCL2 is essential for sperm acrosome formation and male fertility in mice

24 Oct 2022

Abstract excerpt

BACKGROUND: Each year, infertility affects 15% of couples worldwide, with 50% of cases attributed to men. Globozoospermia is an uncommon cause of male factor infertility, characterized by defects in sperm acrosome formation, leading to round-headed spermatozoa. OBJECTIVE: We generated Pdcl2 knockout mice to investigate the essential roles of PDCL2 in mammalian reproduction. MATERIALS AND METHODS: We used reverse...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 36278277
DOI: 10.1111/andr.13329

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