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COX15 deficiency causes oocyte ferroptosis

29 Oct 2024

Abstract excerpt

Mitochondria play diverse roles in mammalian physiology. The architecture, activity, and physiological functions of mitochondria in oocytes are largely different from those in somatic cells, but the mitochondrial proteins related to oocyte quality and reproductive longevity remain largely unknown. Here, using whole-exome sequencing data from 1,024 women (characterized by oocyte maturation arrest and degenerated...

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PMID: 39471219
DOI: 10.1073/pnas.2406174121

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