Article

Stress Granule Formation Drives ZBP1-dependent Necroptosis in Non-obstructive Azoospermia and Aging testes

2025-04-12

Abstract excerpt

Male infertility and age-related reproductive decline remain major unmet medical challenges, with limited understanding of the underlying mechanisms. Here, we identify a stress granule–driven necroptosis pathway involving ZBP1 and RIPK3 as a central driver of non-obstructive azoospermia (NOA) , a severe form of male infertility marked by loss of spermatogenesis. We show that heat stress or environmental insul...

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Literature Corpus work: e0d7072d-0559-502b-b290-a24e1c802cd4
DOI: 10.1101/2025.04.11.648478

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