Article

Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome

2022-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Impaired spermatogenesis and male infertility are common manifestations of mitochondrial diseases, but the underlying mechanisms are unclear. Here we show that mice deficient for PARL, the mitochondrial rhomboid protease, a recently reported model of Leigh syndrome, develop postpubertal testicular atrophy caused by arrested spermatogenesis and germ cell death independently of neurodegeneration....

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Literature Corpus work: 8960274e-d01a-5368-a5c2-3f557fea727b
DOI: 10.1101/2022.11.22.517461

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