Article

Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anti-cancer drug response

2021-01-26

Abstract excerpt

<h4>ABSTRACT</h4> The transcriptional plasticity of cancer cells promotes intercellular heterogeneity in response to anti-cancer drugs and facilitates the generation of subpopulation surviving cells. Characterizing single-cell transcriptional heterogeneity after drug treatments can provide mechanistic insights into drug efficacy. Here we used single-cell RNA-seq to examine transcriptomic profiles of cancer cells...

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Literature Corpus work: 571a2794-b9ac-5d69-b802-dcdef1d571fd
DOI: 10.1101/2021.01.24.427929

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