Article

Refined cellular activity expression signatures provide a targeted framework to quantify phenotypic intra-tumor heterogeneity in single-cell data

2025-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Single cell RNA-seq (scRNA-seq) now allows deeper insight into cellular biology at both the individual and population level. Measuring cell-to-cell variations in the population enables quantification of phenotypic heterogeneity in populations in which cell states and identities deviate from healthy transcriptomic profiles. Cellular activities quantifiable using gene set enrichment analyses can p...

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Literature Corpus work: 0e4cd6de-cc67-544e-9f66-eb023aa792d9
DOI: 10.64898/2025.12.19.695441

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