Article

RECQ4-MUS81 interaction safeguards hard-to-replicate regions to prevent genome instability and Rothmund-Thomson syndrome

2023-12-07

Abstract excerpt

<title>Abstract</title> <p>Replication stress, resulting from hard-to-replicate regions, leads to the accumulation of replication intermediates that need to be processed to ensure successful chromosome segregation. Here we show that RECQ4 physically interacts with MUS81 to target it to DNA substrates and enhance its endonuclease activity. Loss of RECQ4 or its interaction with MUS81 results in chromosomal segregat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5709ca5a-5946-5e02-9bb3-7f8efe9fde29
DOI: 10.21203/rs.3.rs-3672768/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RECQ4-MUS81 interaction safeguards hard-to-replicate regions to prevent genome instability and Rothmund-Thomson syndromeDOI 10.21203/rs.3.rs-3672768/v1Read

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structuresSemantic proximity Read

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and TranscriptionSemantic proximity Read

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.Semantic proximity Read

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.Semantic proximity Read

Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund–Thomson syndromeSemantic proximity Read

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cellsSemantic proximity Read

Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instabilitySemantic proximity Read

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.Semantic proximity Read

MUS81-EME2 Promotes Replication Fork RestartSemantic proximity Read

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiencySemantic proximity Read

The RECQL4 protein, deficient in Rothmund–Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesionsSemantic proximity Read

DNA2 drives processing and restart of reversed replication forks in human cellsSemantic proximity Read