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Article

Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund–Thomson syndrome

1 Feb 2019

Abstract excerpt

RecQ-like helicase 4 (RECQL4) is mutated in patients suffering from the Rothmund-Thomson syndrome, a genetic disease characterized by premature aging, skeletal malformations, and high cancer susceptibility. Known roles of RECQL4 in DNA replication and repair provide a possible explanation of chromosome instability observed in patient cells. Here, we demonstrate that RECQL4 is a microtubule-associated protein...

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PMID: 30718377
DOI: 10.26508/lsa.201800120

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