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Article

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures

7 Nov 2012

Abstract excerpt

RECQ1 is the most abundant of the five human RecQ helicases, but little is known about its biological significance. Recent studies indicate that RECQ1 is associated with origins of replication, suggesting a possible role in DNA replication. However, the functional role of RECQ1 at damaged or stalled replication forks is still unknown. Here, for the first time, we show that RECQ1 promotes strand exchange on...

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PMID: 23095637
DOI: 10.4161/cc.22581

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