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Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteria

8 Aug 2024

Abstract excerpt

Antimicrobial resistance (AMR) is a serious global threat demanding innovations for effective control of pathogens. The bacterial SOS response, regulated by the master regulators, LexA and RecA, contributes to AMR through advantageous mutations. Targeting the LexA/RecA system with a novel inhibitor could suppress the SOS response and potentially reduce the occurrence of AMR. RecA presents a challenge as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39122002
DOI: 10.1016/j.jbc.2024.107650

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Related research

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Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteriaPMID 39122002Read ↗

Boronic acid derivative inhibits LexA mediated SOS response in MycobacteriaSemantic proximity Read ↗

RecA: a universal drug target in pathogenic bacteria.Semantic proximity Read ↗

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Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis.Semantic proximity Read ↗

The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action.Semantic proximity Read ↗

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

The extended N-terminus of Mycobacterium smegmatis RecX potentiates its ability to antagonize RecA functions.Semantic proximity Read ↗

The SOS Response Master Regulator LexA Is Associated with Sporulation, Motility and Biofilm Formation in Clostridium difficile.Semantic proximity Read ↗

Molecular design and functional organization of the RecA protein.Semantic proximity Read ↗

Characterization of the Neisseria meningitidis Helicase RecG.Semantic proximity Read ↗

Review of genus Corynebacterium: with a major focus on AdnAB and DNA recombination repairSemantic proximity Read ↗

recF-dependent recombination as a SOS function.Semantic proximity Read ↗

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