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Article

Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis.

Frontiers in cellular and infection microbiology - 1 Jan 2023

Schuurs Zachariah P, McDonald John P, Croft Laura V, Richard Derek J, Woodgate Roger, Gandhi Neha S

Abstract excerpt

Introduction: As antibiotic resistance has become more prevalent, the social and economic impacts are increasingly pressing. Indeed, bacteria have developed the SOS response which facilitates the evolution of resistance under genotoxic stress. The transcriptional repressor, LexA, plays a key role in this response. Mutation of LexA to a non-cleavable form that prevents the induction of the SOS response sensitizes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36936756
DOI: 10.3389/fcimb.2023.1051602
PMCID: PMC10020695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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