Article
The SOS Response Master Regulator LexA Is Associated with Sporulation, Motility and Biofilm Formation in Clostridium difficile.
PloS one - 1 Jan 2015
Walter Beata M, Cartman Stephen T, Minton Nigel P, Butala Matej, Rupnik Maja
Abstract excerpt
The LexA regulated SOS network is a bacterial response to DNA damage of metabolic or environmental origin. In Clostridium difficile, a nosocomial pathogen causing a range of intestinal diseases, the in-silico deduced LexA network included the core SOS genes involved in the DNA repair and genes involved in various other biological functions that vary among different ribotypes. Here we describe the construction and...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Bacterial Toxins
- Biofilms
- Cell Division
- Clostridioides difficile
- Enterotoxins
- Gene Expression Regulation, Bacterial
- Levofloxacin
- Mutation
- SOS Response, Genetics
- Serine Endopeptidases
- Spores, Bacterial